Be sure to change the toothbrush or toothbrush head (if you are using an electric toothbrush) before brushing and wearing. Not only is the old toothbrush ineffective, but it may also contain harmful bacteria that cause infections like gingivitis and periodontitis. Toothbrush should be replaced every three to four months. The sick person should change the toothbrush at the beginning of the illness, feel good and then change the toothbrush.